Our article in Archipelagu Onkologia

Our article „Rak trzustki – wyzwania i perspektywy” has been published recently in Archipelag Onkologia (http://www.mp.pl/onkologia/). This platform provides up-to-date information to the specialists in the field of oncology. The article is inspired by the results of one of our latest research i.e. the work entitled „Compensatory Metabolic Networks in Pancreatic Cancers Upon Perturbation of Glutamine Metabolism” published in Nature Communications. The article published in Archipelag Onkologia can be found here: TUTAJ

 

Our team develops a program which will support the control of glycemic variability in patients with type I diabetes

A team of scientists from Lodz, which consists of the members of our Department, works on creating a computer program for measuring and modifying blood glucose level in real time. The program is intended to enable the processing of data from sensors used by patients with type I diabetes in order to help stabilize the variability of glycaemia in this population. The team combines specialists from several fields - doctors, statisticians, computer scientists and bioinformaticians from the Department of Biostatistics and Translational Medicine headed by prof. Wojciech Fendler and the team led by dr Andrzej Romanowski from the Institute of Applied Computer Science, Technical University of Lodz. Our team is represented by Konrad Pagacz MD and Przemysław Kucharski MSc, Eng who works on an innovative method of signal analysis that will help determining if a patient's blood glucose level is unstable. Such condition is associated with an increased risk of serious complications such as vision loss or heart failure. Thus early diagnosis is essential because it will allow for rapid and effective modification of the treatment. More information about the project can be found HERE

 

JDRF-ISPAD Research Fellowship for our PhD student!

A major organization of researchers working in pediatric diabetes field - The International Society for Pediatric and Adolescent Diabetes (ISPAD) – together with Juvenile Diabetes Research Foundation (JDRF) – American charity foundation sponsoring research in type 1 diabetes – each year awards 4 young scientists with ISPAD-JDRF Research Fellowship award. It is our pleasure to inform that this year one of ISPAD-JDRF Research Fellowship was awarded to Beata Małachowska MD – a PhD student of prof. Wojciech Fendler from Department of Biostatistics and Translational Medicine. The project Lysophosphatidic acid in pathogenesis of HNF1B-MODY syndrome – the role of kidney and adipose tissue was presented during 17th ISPAD School for Physicians and recommended for this award by the school organization committee.

Congratulation!


 

Our research described at Scientific American

At the beginning of this year at the Science Translational Medicine appeared our article focused on the radiation prediction through microRNAs use. Currently these studies became the subject of discussion in the Scientific American READ HERE

 

Bartłomiej Tomasik awarded during Lodz Oncology Conference

On May 27, The Polish Society of Oncology held a conference at the European Institute in Lodz. The aim of this annual congress is to strengthen scientific integration of oncologists from the region. We are pleased to announce that our PhD student, Bartłomiej Tomasik, was elected the winner of the "Young Oncologists" session. Presented work entitled "Cardiotoxicity after radiotherapy in breast cancer" is the result of cooperation between our Department and Department of Radiation Oncology and Department of Cardiology from Oncohematology Centre in Lodz.
Our study involves the search for cardiotoxicity biomarkers in serum of patients undergoing radiotherapy for breast cancer. Due to the significant improvements in breast cancer treatment, the problem of cardiac toxicity after radiotherapy is becoming increasingly important. The award granted by The Polish Society of Oncology underlines the importance of this issue and motivates us to further research in this field.


 

Job offers!

We are seeking a post-doc researcher and PhD students to work on the „Predictive Biomarkers of Radiation Toxicity (PBRTox)” project.

More details here:

PhD student - stipnd - info here
PhD student - full employment - info here
Post-doc - info here

APPLY HERE

 

Enforcement of Polish-American research collaboration

Thanks to the Mentoring programme of the Foundation for Polish Science professor Wojciech Fendler established a collaboration with prof. Dipanjan Chowdhury from Dana-Farber Cancer Institute (Harvard Institute of Medicine, Boston, USA).
Joint efforts of this two scientists beard fruits such as two publication in Science Translational Medicine (publications) and other excellent works concerning microRNA in cancer and radiotherapy. Dana-Farber Cancer Institute officially included Wojciech Fendler to the Institute’s research team as a Visiting Professor. This is a final knot that binds this two research units. Between 16 and 22th March 2017, our representatives – prof. Fendler and his PhD student and co-author of one of the articles in Science Translational Medicine - Beata Malachowska – visited Dana-Ferber Cancer Institute in order to plan their further work on mutual research projects.

Congratulations to Professor Fendler! We wish him and whole his research team more successes!

 

Wojciech Fendler received the First TEAM grant of the Foundation for Polish Science!

more details here

 

Beata Małachowska received the PRELUDIUM grant

PRELUDIUM is a funding opportunity intended for pre-doctoral researchers about to embark on their scientific career. The competition is organized by National Science Center in Poland. Beata Małachowska was granted for research:Lysophosphatidic Acid in the Pathogenesis of HNF1B-MODY Syndrome

Abstract: "Thanks to collaboration with prof. Wojciech Młynarski – a head of Department of Pediatrics, Oncology, Hematology and Diabetology (Medical University of Lodz) that runs Polish Registry for Pediatric and Adolescent Diabetes in which previously worked both prof. Fendler and dr Malachowska – unique serum samples of molecularly diagnosed rare monogenic diabetes patients undergone metabolomics fingerprinting analysis. In-depth data analysis, revealed which metabolites are characteristic for patients with mutations within HNF1B gene. Further, to evaluate if those metabolites are engaged into pathogenesis of symptoms observed in HNF1B-MODY (Maturity Onset Diabetes of the Young) patients, we performed in vitro studies on hepatic cell lines with knock-down of HNF1B expression with stimulation of selected deregulated metabolites to evaluate the changes caused by this compound. This research project is funded by Preludium Grant (2016/21/N/NZ5/01448, National Science Centre Poland) which principal investigator is dr Malachowska. Metabolomic fingerprinting is also harnessed in another research project conducted with collaboration with Department of Pediatrics, Oncology, Hematology and Diabetology. It is focused on searching for simple, long-lasting serum biomarkers of acute diabetes complications in children (diabetes ketoacidosis and hypoglycemia). This project is a part of PhD thesis of dr Malachowska and is financed by Polish Diabetes Grant".

Bartłomiej Tomasik received the PRELUDIUM grant

Bartłomiej Tomasik was granted for research: MicroRNA profile in oropharyngeal cancer and its utility in radiotoxicity monitoring.

Abstract: "We intend to identify specific microRNA profile in 2 groups of patients who have undergone radiotherapy due to oropharyngeal squamous cell carcinoma (OPSCC). First cohort will consist of the patients who have experienced complications after radiotherapy and the second will comprise those in whom toxicity has not occurred. Then, by validation of most differentially expressed microRNAs on a larger group of patients, we will assess the clinical utility of microRNAs as biomarkers in OPSCC. We deem that the analysis of microRNAs, preselected after global profiling, in patients with OPSCC might be useful in early treatment-related toxicity prevention and treatment monitoring."

 

Beata Małachowska granted by Polish Diabetes Association

Abstract: Type 1 diabetes in children characterized by great lability of glycemic control and thus tendency to hypoglycemia (low blood sugar) and diabetes ketoacidosis. We may diagnose those diabetes complication when they are ongoing, however we lack long-lasting markers of exposure to them. Our study aims at finding simple, long-lasting markers of hypoglycemia and diabetes ketoacidosis by means of metabolomic studies approach. The project is carried out with cooperation with Department of Pediatrics, Oncology, Hematology and Diabetology and Medical University of Białystok. The project is a part of PhD thesis of Beata Małachowska and is financed by Research Grant from Diabetes Poland.

 

Beata Małachowska achieved Polpharma Scholarship