Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | brain2_tissuebrain_collapsed_to_symbols.Brain_tissue_TIRRKO_vs_Brain_control.cls #Brain_tissue_TIRRKO_versus_Brain_control.Brain_tissue_TIRRKO_vs_Brain_control.cls #Brain_tissue_TIRRKO_versus_Brain_control_repos |
| Phenotype | Brain_tissue_TIRRKO_vs_Brain_control.cls#Brain_tissue_TIRRKO_versus_Brain_control_repos |
| Upregulated in class | Brain_control |
| GeneSet | KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY |
| Enrichment Score (ES) | -0.31277153 |
| Normalized Enrichment Score (NES) | -0.98377204 |
| Nominal p-value | 0.5247748 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | MAPK13 | mitogen-activated protein kinase 13 [Source:HGNC Symbol;Acc:HGNC:6875] | 362 | 0.538 | 0.0276 | No |
| 2 | FADD | Fas associated via death domain [Source:HGNC Symbol;Acc:HGNC:3573] | 427 | 0.507 | 0.0690 | No |
| 3 | TRIM25 | tripartite motif containing 25 [Source:HGNC Symbol;Acc:HGNC:12932] | 885 | 0.352 | 0.0748 | No |
| 4 | RELA | "RELA proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955]" | 1605 | 0.224 | 0.0547 | No |
| 5 | DHX58 | DExH-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:29517] | 2434 | 0.146 | 0.0215 | No |
| 6 | NLRX1 | NLR family member X1 [Source:HGNC Symbol;Acc:HGNC:29890] | 2548 | 0.136 | 0.0273 | No |
| 7 | TKFC | triokinase and FMN cyclase [Source:HGNC Symbol;Acc:HGNC:24552] | 2642 | 0.130 | 0.0337 | No |
| 8 | IFNW1 | interferon omega 1 [Source:HGNC Symbol;Acc:HGNC:5448] | 2901 | 0.112 | 0.0293 | No |
| 9 | IFNA13 | interferon alpha 13 [Source:HGNC Symbol;Acc:HGNC:5419] | 3077 | 0.102 | 0.0286 | No |
| 10 | IFIH1 | interferon induced with helicase C domain 1 [Source:HGNC Symbol;Acc:HGNC:18873] | 3191 | 0.095 | 0.0308 | No |
| 11 | MAPK11 | mitogen-activated protein kinase 11 [Source:HGNC Symbol;Acc:HGNC:6873] | 3907 | 0.058 | -0.0039 | No |
| 12 | IKBKE | inhibitor of nuclear factor kappa B kinase subunit epsilon [Source:HGNC Symbol;Acc:HGNC:14552] | 4027 | 0.052 | -0.0059 | No |
| 13 | MAPK12 | mitogen-activated protein kinase 12 [Source:HGNC Symbol;Acc:HGNC:6874] | 4177 | 0.045 | -0.0103 | No |
| 14 | NFKBIB | NFKB inhibitor beta [Source:HGNC Symbol;Acc:HGNC:7798] | 4317 | 0.038 | -0.0146 | No |
| 15 | ISG15 | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] | 5033 | 0.007 | -0.0539 | No |
| 16 | IFNA14 | interferon alpha 14 [Source:HGNC Symbol;Acc:HGNC:5420] | 5317 | 0.000 | -0.0696 | No |
| 17 | IFNA16 | interferon alpha 16 [Source:HGNC Symbol;Acc:HGNC:5421] | 5318 | 0.000 | -0.0696 | No |
| 18 | IFNA10 | interferon alpha 10 [Source:HGNC Symbol;Acc:HGNC:5418] | 5319 | 0.000 | -0.0696 | No |
| 19 | IFNA7 | interferon alpha 7 [Source:HGNC Symbol;Acc:HGNC:5428] | 5418 | 0.000 | -0.0751 | No |
| 20 | IFNA1 | interferon alpha 1 [Source:HGNC Symbol;Acc:HGNC:5417] | 5419 | 0.000 | -0.0751 | No |
| 21 | IFNA8 | interferon alpha 8 [Source:HGNC Symbol;Acc:HGNC:5429] | 5420 | 0.000 | -0.0751 | No |
| 22 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 5427 | 0.000 | -0.0754 | No |
| 23 | IFNK | interferon kappa [Source:HGNC Symbol;Acc:HGNC:21714] | 5465 | 0.000 | -0.0775 | No |
| 24 | PIN1 | "peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988]" | 6163 | -0.006 | -0.1157 | No |
| 25 | IL12B | interleukin 12B [Source:HGNC Symbol;Acc:HGNC:5970] | 6362 | -0.013 | -0.1256 | No |
| 26 | MAVS | mitochondrial antiviral signaling protein [Source:HGNC Symbol;Acc:HGNC:29233] | 6890 | -0.029 | -0.1523 | No |
| 27 | IKBKG | inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [Source:HGNC Symbol;Acc:HGNC:5961] | 6988 | -0.032 | -0.1549 | No |
| 28 | TRADD | TNFRSF1A associated via death domain [Source:HGNC Symbol;Acc:HGNC:12030] | 7083 | -0.034 | -0.1571 | No |
| 29 | IL12A | interleukin 12A [Source:HGNC Symbol;Acc:HGNC:5969] | 7145 | -0.036 | -0.1574 | No |
| 30 | OTUD5 | OTU deubiquitinase 5 [Source:HGNC Symbol;Acc:HGNC:25402] | 7462 | -0.045 | -0.1709 | No |
| 31 | NFKBIA | NFKB inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:7797] | 7893 | -0.058 | -0.1897 | No |
| 32 | DDX3Y | DEAD-box helicase 3 Y-linked [Source:HGNC Symbol;Acc:HGNC:2699] | 8057 | -0.063 | -0.1932 | No |
| 33 | DDX3X | DEAD-box helicase 3 X-linked [Source:HGNC Symbol;Acc:HGNC:2745] | 8275 | -0.068 | -0.1993 | No |
| 34 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 8696 | -0.081 | -0.2155 | No |
| 35 | MAPK10 | mitogen-activated protein kinase 10 [Source:HGNC Symbol;Acc:HGNC:6872] | 8947 | -0.087 | -0.2217 | No |
| 36 | IFNE | interferon epsilon [Source:HGNC Symbol;Acc:HGNC:18163] | 9056 | -0.090 | -0.2197 | No |
| 37 | TANK | TRAF family member associated NFKB activator [Source:HGNC Symbol;Acc:HGNC:11562] | 9211 | -0.094 | -0.2199 | No |
| 38 | MAPK9 | mitogen-activated protein kinase 9 [Source:HGNC Symbol;Acc:HGNC:6886] | 9255 | -0.096 | -0.2138 | No |
| 39 | AZI2 | 5-azacytidine induced 2 [Source:HGNC Symbol;Acc:HGNC:24002] | 9487 | -0.103 | -0.2175 | No |
| 40 | MAP3K1 | mitogen-activated protein kinase kinase kinase 1 [Source:HGNC Symbol;Acc:HGNC:6848] | 10160 | -0.122 | -0.2441 | No |
| 41 | ATG5 | autophagy related 5 [Source:HGNC Symbol;Acc:HGNC:589] | 10710 | -0.137 | -0.2625 | No |
| 42 | NFKB1 | nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] | 11615 | -0.166 | -0.2981 | Yes |
| 43 | TNF | tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] | 11684 | -0.168 | -0.2869 | Yes |
| 44 | ATG12 | autophagy related 12 [Source:HGNC Symbol;Acc:HGNC:588] | 12037 | -0.180 | -0.2905 | Yes |
| 45 | MAP3K7 | mitogen-activated protein kinase kinase kinase 7 [Source:HGNC Symbol;Acc:HGNC:6859] | 12251 | -0.188 | -0.2857 | Yes |
| 46 | IFNA2 | interferon alpha 2 [Source:HGNC Symbol;Acc:HGNC:5423] | 12267 | -0.188 | -0.2698 | Yes |
| 47 | DDX58 | DExD/H-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:19102] | 12305 | -0.190 | -0.2550 | Yes |
| 48 | TRAF3 | TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033] | 12425 | -0.194 | -0.2444 | Yes |
| 49 | TBK1 | TANK binding kinase 1 [Source:HGNC Symbol;Acc:HGNC:11584] | 12505 | -0.197 | -0.2313 | Yes |
| 50 | CYLD | CYLD lysine 63 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:2584] | 13110 | -0.220 | -0.2454 | Yes |
| 51 | TBKBP1 | TBK1 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:30140] | 13271 | -0.227 | -0.2341 | Yes |
| 52 | TRAF6 | TNF receptor associated factor 6 [Source:HGNC Symbol;Acc:HGNC:12036] | 14158 | -0.271 | -0.2594 | Yes |
| 53 | STING1 | stimulator of interferon response cGAMP interactor 1 [Source:HGNC Symbol;Acc:HGNC:27962] | 14286 | -0.277 | -0.2418 | Yes |
| 54 | MAPK8 | mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881] | 14559 | -0.293 | -0.2310 | Yes |
| 55 | TRAF2 | TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032] | 14934 | -0.314 | -0.2240 | Yes |
| 56 | CHUK | component of inhibitor of nuclear factor kappa B kinase complex [Source:HGNC Symbol;Acc:HGNC:1974] | 15701 | -0.371 | -0.2336 | Yes |
| 57 | MAPK14 | mitogen-activated protein kinase 14 [Source:HGNC Symbol;Acc:HGNC:6876] | 15757 | -0.376 | -0.2034 | Yes |
| 58 | IKBKB | inhibitor of nuclear factor kappa B kinase subunit beta [Source:HGNC Symbol;Acc:HGNC:5960] | 16122 | -0.406 | -0.1876 | Yes |
| 59 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 16413 | -0.439 | -0.1648 | Yes |
| 60 | CASP8 | caspase 8 [Source:HGNC Symbol;Acc:HGNC:1509] | 16880 | -0.512 | -0.1453 | Yes |
| 61 | RNF125 | ring finger protein 125 [Source:HGNC Symbol;Acc:HGNC:21150] | 17059 | -0.545 | -0.1068 | Yes |
| 62 | IRF3 | interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] | 17171 | -0.574 | -0.0621 | Yes |
| 63 | SIKE1 | suppressor of IKBKE 1 [Source:HGNC Symbol;Acc:HGNC:26119] | 17306 | -0.609 | -0.0155 | Yes |
| 64 | RIPK1 | receptor interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:10019] | 17366 | -0.627 | 0.0369 | Yes |
