Type 1 diabetes (T1D) is the most common metabolic disease in childhood. It is caused by the destruction of pancreatic beta cells by one’s malfunctioning immune system. The lost beta cells are responsible for the production of insulin – an essential hormone in blood glucose levels regulation. Treatment of T1D demands life-long subcutaneous insulin supplementation […]

Transplantation of hematopoietic stem cells from bone marrow is a widely used method for treating various diseases, such as blood cancers, metabolic disorders, and autoimmune diseases. However, some patients are unable to undergo this procedure effectively due to problems with mobilizing an adequate number of stem cells. The study proposes to evaluate the role of […]

The project aims to investigate the role of proinsulin C-peptide and G-protein coupled receptor 146 (GPR146) in type 2 diabetes mellitus (T2DM) complications. C-peptide is a short peptide that influences multiple cellular pathways, and its role in diabetes complications has become increasingly evident. The study postulates that C-peptide interacts with the GPR146 receptor, which may […]

Colorectal cancer (CRC) is the second leading cause of cancer death in the world. Standard treatment of patients with locally advanced cancer of the rectum includes chemoradiotherapy (CHRT) before surgery. In recent years, the new standard of treatment for some patients with CRC has become immunotherapy with the use of so-called immune checkpoint inhibitors (ICI) […]